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“After testing negative for COVID-19 on Monday during her regular testing cadence, the First Lady began to develop cold-like symptoms late in the evening,” her spokeswoman Elizabeth Alexander said in a statement. “She tested negative again on a rapid antigen test, but a PCR test came back positive.”

Alexander noted that Jill Biden, 71, is “double-vaccinated, twice boosted and only experiencing mild symptoms.” The first lady has been prescribed the antiviral therapy Paxlovid and will isolate from others for at least five days, in accordance with guidance from the Centers for Disease Control and Prevention.

“Close contacts of the First Lady have been notified,” Alexander said. “She is currently staying at a private residence in South Carolina and will return home after she receives two consecutive negative COVID tests.”

The first lady’s positive test comes a few weeks after President Biden, 79, tested positive for the coronavirus on July 21. The president tested negative for the coronavirus Tuesday morning on an antigen test, White House press secretary Karine Jean-Pierre said.