LA County releases lab-raised mosquitoes to fight mosquitoes

In Los Angeles, those who wage war on mosquitoes are adding a weapon to their arsenal: more mosquitoes.

The Greater Los Angeles County Vector Control District launched a pilot program this week to release tens of thousands of irradiated, lab-raised mosquitoes into the local environment. These mosquitoes are all male and have been sterilized by the radiation, so the hope is that they will find wild female mates and impregnate them with dead-end sperm, rendering the resulting eggs worthless. 

The target is a particular species, Aedes aegypti. The insects, which began to populate Los Angeles County in 2014, have evolved to hone in on one thing — you. 

“Thousands of years ago, a strain of Aedes aegypti moved in close to people and started to specialize to live near houses and bite people,” said Daniel Hahn, a professor in the University of Florida’s Department of Entomology and Nematology. “They’re characterized as aggressive nuisance biters because they’ll bite you all day long.”

Aedes Aegypti thrive in backyards and make their homes in small containers like bottle caps and dog bowls. They can carry worrisome diseases like yellow fever, Chikungunya, Zika and dengue. 

“We know our residents are suffering,” said Susanne Kluh, the general manager of the Greater Los Angeles County Vector Control District, which serves 6 million people and has more than 90 full-time staffers.  

The district on Thursday released about 20,000 sterile male mosquitoes, dyed to appear fluorescent under a black light, as part of its final pilot program test. Male Aedes Aegypti mosquitoes don’t bite, so experts say the program poses near-zero risk to humans. 

Next month, the district plans to release seven to 10 sterile mosquitoes for every wild male they believe is living in the target region, the Sunland-Tujunga area of LA. That could be up to 60,000 mosquitoes per week. 

The strategy is an example of the ways humans are deploying novel technology to fight the spread of invasive mosquitoes and the diseases they can carry, as climate change, global trade and urbanization propel the pests into new territory.

“They’ve evolved specifically to exploit humans as their hosts, and so we are constantly in an arms race against them,” Hahn said. 

An expanded range for aggressive mosquitoes

The Aedes Aegypti mosquito is not native to the United States but has been in some regions for hundreds of years. They have even played central roles in American history: In 1793, they forced some federal officials to flee Philadelphia, when the city was the seat of the U.S. government, because of an outbreak of yellow fever.

In recent years, researchers have warned that higher temperatures due to climate change will broaden the species’ range. That appears to be what happened in Southern California.

The state recorded its first two cases of locally acquired dengue fever last year, which meant local mosquitoes were transmitting the virus. 

“Everybody always said, well, our weather isn’t suitable, but you know, the mosquitoes adapt and our weather has changed,” Kluh said. “We get more moisture in the summer, and people create these ideal little moist mini climates in their backyards, with lush plants and everything.”

The region has also seen urban and suburban sprawl, which has expanded habitat for Aedes Aegypti. 

Fighting mosquitoes with mosquitoes

The weaponized mosquitoes were bred in a Kentucky laboratory but developed from eggs sourced from the LA area. Each week, the vector district plans to hatch mosquitoes in tiny insect dorms then give them a zap of radiation from a specialty machine. Once released, the irradiated mosquitoes will fly only about 150 meters, Kluh said. 

Hahn, who is not involved in the LA project, said the blast of radiation chops up the chromosomes within the mosquitoes’ cells, preventing reproduction while still allowing the insects to fly and perform other biological functions at near-normal levels. 

Kluh said the mosquitoes won’t be radioactive and won’t pose risk to the public. 

The district has spent about $255,000 of its $24.8 million annual budget on the program, she added: “We’ve done this on the cheap.”

Still, Kluh said it would be a challenge to scale the program across more of Los Angeles County. Instead, she envisions it as a targeted treatment for Aedes Aegypti hotspots and areas where cases of mosquito-carried diseases are reported. 

Other regions are pursuing similar technology. In Florida, Lee County began a program to release sterile, irradiated mosquitoes in 2017. Several other California districts are also piloting the program or have purchased irradiators. 

New approaches to pest control

The idea of irradiating pests to bring populations down is not new. The agricultural industry has been irradiating male fruit flies for about three decades, according to Hahn. 

Mosquito programs were developed 40 years ago, he said, but ultimately “got left behind because it wasn’t cost effective.”

Since then, however, mosquitoes have evolved to resist some common pesticides, creating a need for new solutions. 

Some companies are pursuing other technologies to fight Aedes Aegypti, like genetically modifying male mosquitoes so they kill females, releasing male mosquitoes that carry a particular bacteria or seeding a dominant gene into the population to drive numbers down.

Hahn said some of these ideas carry a risk of unintended consequences but are worth researching nonetheless. Such technologies are regulated by the Environmental Protection Agency, and some are being tested in small pilot programs. 

But irradiation programs are not regulated, which makes them the weapon of choice in the U.S. today. 

“We wanted to start something now,” Kluh said.